Alternatively Spliced Human TREK-1 Variants Alter TREK-1 Channel Function and Localization1
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منابع مشابه
Alternatively Spliced Human TREK-1 Variants Alter TREK-1 Channel Function and Localization.
TREK-1, an outward-rectifying potassium channel activated by stretch, is found in the myometrium of pregnant women. Decreased expression of TREK-1 near term suggests that TREK-1 may contribute to uterine quiescence during gestation. Five alternatively spliced TREK-1 variants were identified in the myometrium of mothers who delivered spontaneously preterm (<37 wk), leading to the hypothesis that...
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Mechanosensitive and voltage-gated ion channels are known to perform important roles in mechanotransduction in a number of connective tissues, including bone and muscle. It is hypothesized that voltage-gated and mechanosensitive ion channels also may play a key role in some or all initial responses of human tenocytes to mechanical stimulation. However, to date there has been no direct investiga...
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Two-pore domain (K2P) potassium channels are the major molecular correlates of the background (leak) K(+) current in a wide variety of cell types. They generally play a key role in setting the resting membrane potential and regulate the response of excitable cells to various stimuli. K2P channels usually function as homodimers, and only a few examples of heteromerization have been previously re...
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Earlier studies have demonstrated that the tandem pore domain weak inward rectifying K⁺ channel (TWIK)-related K⁺ (TREK)-1 channel is inhibited by antidepressants and is associated with major depression. However, little is known about the effect of mood stabilizers that are commonly used for treatment of bipolar disorder on TREK channels, members of the two-pore domain K⁺ (K2P) channel family. ...
متن کاملJPET # 84418 1 Zinc activates TREK - 2 potassium channel activity
The number of text pages: 28 pages The number of tables: 0 The number of figures: 4 figures The number of references: 30 references The number of words in the abstract: 163 words The number of words in the introduction: 531 words The number of words in the discussion: 1104 words This article has not been copyedited and formatted. The final version may differ from this version. JPET#84418 3 ABST...
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ژورنال
عنوان ژورنال: Biology of Reproduction
سال: 2015
ISSN: 0006-3363,1529-7268
DOI: 10.1095/biolreprod.115.129791